Five Simple Exercises to Prevent Age-Related Muscle Loss

By Tom Michaud, D.C.

It’s a depressing fact but shortly after age 50, you begin to lose nearly 2 percent of your muscle fibers each year. Figure 1 is a graph of the average number of quadriceps muscle fibers present in adults aged 18 to 82. Looking at the center of the graph, you can see how the number of muscle fibers remain stable through your 30s and 40s. After that, muscle mass declines rapidly, dropping from 600,000 muscle fibers at age 50 to 320,000 muscle fibers by age 80. Unfortunately, the reduction in muscle mass is associated with a 3-fold reduction in strength and power, which begins a downward spiral of frailty that correlates strongly with disability, falls, and reduced lifespan. Several studies have shown that age-related muscle loss (also known as sarcopenia) is associated with the development of osteoarthritis, heart disease, stroke, diabetes, hypertension, cognitive decline and even cancer.

Fig. 1. Total number of fibers present in the quadriceps muscles of men between the ages of 18 and 82 years (1).

While research confirms that regular exercise can reduce the speed of muscle wasting, there is a surprising amount of controversy regarding what type of exercise is best for maintaining muscle mass. According to the American College of Sports Medicine, the only way to effectively build muscle is to perform multiple sets of 8 to 12 repetitions using heavy weights. The theory is that heavy weights are needed to recruit the maximum number of muscle fibers in order to stimulate remodeling. The problem with using heavy weights is that as people age and muscle fibers begin to disappear, the vanishing muscle fibers are replaced with fat and scar tissue, which significantly weakens muscles and tendons. Age-related weakening of muscle fibers explains why seniors are 10-times more likely to be injured while lifting heavy weights compared to their younger peers.

Luckily, a growing body of research shows it is possible to build muscle mass using light resistance exercise. In 2013, researchers compared changes in muscle volume in subjects who performed conventional high resistance weight training (2 sets of 10-15 reps performed at near full effort), with subjects who performed one set of 60 repetitions at 15% of full effort, followed immediately with one set of 12 repetitions performed at 40% full effort; i.e., the subjects were exhausted after the 60th and after the 12th repetition, respectively. The researchers were surprised that the low intensity routine produced the same gains in muscle volume as high-intensity weight training. They state that prior to their study, “virtually no studies have focused on the effects of such high-repetition protocols.”

In 2018, researchers from Japan had 88 men and women aged 70 years or older participate in a weight-training program in which they performed two sets of 10 to 14 repetitions daily for 12 weeks. The subjects used body weight alone and performed the movements very slowly (4-seconds up and 4-seconds down). At the end of the 12-week training program, in addition to significant increases in muscle mass, participants also had decreased hip and waist circumference and reduced abdominal fat. This study is remarkable because the participants had no prior experience with weight training, the exercises were performed at home (taking less than 15 minutes each day), and at the end of the study, only two of the 88 people involved dropped out.

In a 2019 study, researchers measured muscle hypertrophy following a 10-week exercise routine in which subjects performed 1 set of exercises lifting either heavy weights (80% full effort), or light weights (30% full effort) until they were fatigued. (Usually, subjects lifting weights at 30% full effort fatigue after 20-25 repetitions.) Surprisingly, while both protocols increased muscle strength and volume, only the light weights resulted in a significant increase in the number of mitochondrial proteins associated with accelerated repair and remodeling. Although the exact mechanism is unclear, it is theorized that the higher number of repetitions produces a greater increase in intramuscular pressure, essentially squeezing blood out of the muscle. The reduced blood flow decreases oxygen levels, causing a shift in muscle recruitment from just a few slow-twitch muscle fibers (which are dependent upon oxygen) to a much larger number of fast-twitch muscle fibers (which can function in an oxygen-free environment). The more fast-twitch muscle fibers recruited with each set, the more specialized cells called satellite cells work to stimulate remodeling. Apparently, long rests between sets allow for the restoration of blood flow, which restores circulation and allows the body to go back to using just a few slow-twitch muscle fibers.

Figure 3 reviews 5 simple exercises to maintain muscle mass in nearly every muscle of the body. A video of the exercises is available at This routine, which can be performed at home without special equipment, takes about 15 minutes to complete and should be repeated at least twice a week. Because the body adapts to specific exercise protocols, vary sets and repetitions on 12-week cycles. Some of the sets should be performed quickly and some slowly. The most important factor is to begin strength training early in life because it is not possible to increase the total number of muscle fibers in the body; it is only possible to maintain existing muscle fibers.

Fig. 2. Satellite cells surround muscle fibers (especially fast-twitch muscle fibers) and are responsible for muscle repair.


Fig. 3. The Sarcopenia Workout.

A: Straight arm pull back. Attach a Theraband to a door and pull straight back, moving your shoulder blades down and back. This exercise targets the lower trapezius (an important postural muscle), the triceps, and the forearm flexors. Perform 1 set of 60, followed immediately by 1 set of 12 to fatigue.

B: Oblique twist and lift. With the Theraband at waist level, step sideward until the band is on tension (horizontal arrow). Maintain tension as you raise and lower the Theraband 25 times (vertical arrow). Face the opposite direction and repeat. This exercise targets the abdominal obliques, rhomboids, and serratus anterior.

C: Partial forward lift. Hold a weighted sandbag or backpack just above the knees and use your knees, hips, shoulders and arms to lift the bag upward (arrow). The lumbar spine should be maintained in a neutral position and you should use enough weight to be fatigued after 25 repetitions. Repeat 2 times. This is an excellent functional exercise that targets the quads, glutes, low back, anterior deltoids, and biceps. If you have a history of shoulder injuries, don’t lift the bag above your head.

D: Heel raises. While standing on a ToePro exercise platform, perform heel raises while vigorously forcing your toes into the foam. Perform one set of 60, followed immediately with one set of 12. Because the ToePro platform tilts laterally and is elevated beneath the toes, it places the peroneal and arch muscles in a stretched position, which produces a fourfold increase in strength compared to conventional exercises. Maintaining toe strength is important because toe weakness is the single best predictor of falls in the elderly.

E: Lateral step-ups with weighted bag. Using the same weight used in exercise C, place one foot on a 4- to 6-inch platform and do 25 repetitions stepping up onto the platform while holding onto a wall or stable surface. The stepping knee should not twist in and it should bend only a small amount. Bending the knee more than 45 degrees (as with squats) produces dangerous amounts of pressure on the back of the kneecap. Lateral step-ups have been shown to effectively target the inner quad and hip musculature, while placing very little strain on the knee itself. Performing a slight hip hinge while raising and lowering the weight allows you to isolate the hip rotators and abductors. Perform 2 sets of 25 repetitions on each leg.


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